IDAAM Publications

Volume 1

January-March 2023

Vidya A Kheradkar, Jameel Ahmed S Mulla‎

Phytosomes are the advanced drug delivery. The primary goal of this research is to concentrate on phytosomes, which are widely utilised as the greatest technology in the pharmaceutical industry because to their expanded therapeutic benefit and unique adverse effects. The main objective of this review is to focus on Phytosomes which are being used large as best technology in pharmaceutical field because of expands their therapeutic effect and minimize unusual side issues. Phytosomes is a news specific technology developed to integrate standardized plant extracts into phospholipids to give a lipid soluble molecular complex with boosted bioavailability and absorption, which is termed as “phytosomes”. The two words that make up phytosomes are “Phyto” and “Some,” both of which refer to plants and cells, respectively. The review’s first section introduces phytosomes technology and highlights its benefits, while its second section gives an overview of preparation techniques, evaluation, and possible applications. A brand-new, unique technology called phytosomes was developed to incorporate regular plant extract into phospholipid to produce a molecular complex that is lipid soluble .It is enhanced pharmacokinetics and bioavailability. It is used for develop the pharmaceutical formulation for improve bioavailability of herbal phyto constituents. This is advanced form of herbal formulations which encompasses the bioactive phytoconstituents of herb extracts surround and fated by a lipid. The present review brief description the highpoint of phytosomes technology, preparation methods, advantages, properties, evaluation and application of phytosomes.
Keywords: Phytosomes, Drug Delivery System, Plant Extract, Phospholipid, Advanced.

Akshay R Yadav , Aishwarya C Patil, Yogita T Rayate, Prashant S ‎Salunkhe, Pravin P Honmane‎

The objective of the analysis is to determine the inhibitory function of α-amylase active ‎compounds in Barleria prionitis L. Usage in studies of silico docking. In this respect the docking ‎evaluation was for active plant constituent ligands. The standard inhibitor was acarbose, a known ‎α-amylase inhibitor. The latest version of GLIDE Software v5.5 developed by Schrödinger has ‎taken the place of silico docking studies. These results demonstrate that binding energy ranged ‎from – 3.1 to -8.9 kcal/mol in all active components. If compared (-6.3 kcal/mol) to the norm. The ‎inhibitors of α-amylase are excellent because of their structural parameters, as well as 1,8-‎dihydroxy-2,7-dimethyl 3,6-dimethoxy anthraquinone and Melilotic acid and Barlerin. Through ‎these molecular docking studies, the effective α-amylase inhibitors for the treatment of diabetes ‎are further developed.‎‎
Keywords: Barleria prionitis L., Molecular Docking, α-Amylase, Anti-diabetic.‎

Akshay R Yadav, Swapnali A Thorat

Plants play an important role on the earth, and humans depend on them for their medicinal ‎properties. Medicinal plants are commonly used in the health-care delivery system, either as a ‎single drug or in combination. Helminthes infections are among the most common infections ‎in humans, affecting a significant portion of the global population. Although the majority of ‎helminth infections are confined to tropical areas, they pose a significant health risk and lead ‎to the prevalence of malnutrition, anaemia, eosinophilia, and pneumonia. Parasitic diseases ‎cause a high incidence of morbidity in people living in endemic areas. The antihelmintic ‎activity of ethyl acetate and ethanolic extracts of Lawsonia inermis Linn leaves against ‎Pheretima posthuma and Ascardia galli is currently being investigated. In the bioassay, ‎various concentrations were used, and the worms were paralysed and died after a certain ‎period of time. Both extracts were found to have significant antihelmintic activity.‎
Keywords: Lawsonia inermis Linn, Anthelmintic Activity,  Ascardia GalliPheretima Posthuma.‎

Akshay R Yadav ‎

In current research, Malvastrum Coromandelianum plants have been subjected to ‎macroscopic and microscopic studies. Microscopic features revealed that the leaf was dorsiventral. Two types of trichomes were observed: sessile, ‎unicellular, uniserated, and bi-cellular glandular head covering. The vascular ‎bundle was coated with spongy parenchyma. Alkaloids, tannins, flavonoids, ‎carbohydrates, and saponins were detected by phytochemical screening.‎
Keywords: Malvastrum Coromandelianum, ‎ Macroscopic, ‎ Microscopic Studies, ‎ Phytochemical Screening.‎