Abstract: Nanoparticles are becoming key components in a extended type of applications and Nanoparticles are mostly used extensively for applications in drug discovery, drug delivery, diagnostics and for many others in medical field. In development of different dosage forms to deliver the drugs have been in use, the evolution and modern trends in the science and technology help the pharmaceutical companies to focus on the novel approches. Nanotechnology is an extremely powerful emerging technology to modify the pharmacokinetic and pharmacodynamics activity of the drug medication system like nanoparticles has physical application. Scientists are to make traces in the field of nanotechnology to reformulate the existing essential drugs to minimize the harmful effects and to increase the therapeutic efficacy. This article on NDDS seeks to provide that advances in the field of NDDS are helpful in overcoming various problems and challenges with the current trends, the technology and science have future prospects that enable the healthcare professionals to develop even better applications to serve the human kind and also Disease detection, therapy and diagnosis can be done by advanced nanotechnology. Use of nanotechnology in nano-vaccine, targeted drug delivery system, Green Nanotechnology and Glucose Nanosensors will be discussed.