Many pharmaceutical companies switch their products from tablets to oral thin films (OTFs) that dissolve easily. Films have all the advantages of tablets (precise dose, simple administration) and those of liquid dosage types (easy swallowing, rapid bioavailability). Statistics have shown that four out of five patients prefer orally disintegrating dosage forms to traditional strong oral dosages forms. There is trouble swallowing or chewing solid drug formulations in pediatric, geriatric, bedridden, emetic patients and those with Central Nervous System disorders. Many of these patients are non-compliant in administering solid dosage forms due to fear of choking. OTFs are immediately wet with saliva when put on the tip or the floor of the tongue. As a consequence, OTFs hydrate quickly and then disintegrate and/or dissolve to release the local and/or systemic absorption drug. This technology offers a good forum for the production of patent-free products and for the extension of the patent life cycle of existing products. Not only is the use of quick dissolving oral thin films restricted to the oral rapid dissolving system, but it also applies to other applications such as gastroretentive sublingual delivery systems. This review highlights the special features, component, classification and techniques used in preparation of fast dissolving films.
Keywords: Fast Dissolving Films, Oral Cavity, Solvent Casting Hot Melt Extrusion, Solid Dispersion Extrusion.
Oral delivery of lipophilic drugs faces major challenges due to low aqueous solubility of such compounds. Self Nano-emulsifying drug delivery systems (SNEDDSs) have ability to increase solubility and bioavailability poorly soluble drugs. SNEDDS are isotropic mixtures of oils, surfactants, solvents and co-solvents/co-surfactants that can be used for the design of formulations in order to improve oral absorption of highly llipophilic drug compounds. The Self Nanoemulsifying Drug Delivery System (SNEDDS) is important application on BCS class II and class VI drugs for improving water solubility of poorly water soluble drugs and improve bioavailability. Various surfactants and oils were screened as candidates for SNEDDS on the basis of droplet size of resulting emulsions. This review offers an updated overview of SNEDDS application from the biopharmaceutical point of view.
The controlled drug delivery systems consist in technologies that aim to release therapeutic agents in a specific target as needed to achieve the desired therapeutic outcome. Controlled release systems are well used to control the drug plasma concentration after administration by various possible routes. They can play the important part in targeted drugs delivery system in organs or tissues. It is to ensure safety and to improve strength of the drug as well as patient compliances. Pharmaceutical discovery and research are increasingly focused on delivery systems that enlarge desirable therapeutic objectives while decreasing the side effects. The maintenance of the concentration of drug in the plasma in therapeutic index is most important for effectual treatment. The controlled release drug delivery system works on many different mechanisms to regulate the release rate of drugs. Various mechanisms like osmotic pressure, matrix system, reservoir system etc. It also discusses the usual drug delivery systems and in addition controlled drug delivery systems are mentioned in detail with the design, classifications and drawings features. This article provides on an ideal requirement and different approaches, advantages, properties, types involved in the evolution of controlled release drug delivery system for the better delivery of the drugs.
Keywords: Drug Delivery System, Controlled Release, Pharmacokinetics,Dosage Forms, Drug Release, Dose Size, Release Rate.
Abstract: Vaccination is without a doubt the most efficient disease preventive and eradication health measure. Nonetheless, there is still a need to improve immunization coverage over the world. The utilisation of delivery vehicles capable of producing an effective immune response while also improving stability, safety, and cost effectiveness is a viable technique for achieving this aim today. Vaccination with MN devices addresses the skin’s complex immune system, resulting in greater antigen utilisation and a stronger immunological response, generally with a smaller vaccination dose than with traditional delivery methods. Despite the numerous benefits and nearly four decades of research, there are now only a few licenced MN-based vaccinations available. This article focuses on types of microneedles for vaccine delivery, advantages and disadvantages and evaluation of microneedles
Pharmaceutical innovation and research are putting more and more emphasis on delivery methods that maximise therapeutic outcomes while minimising negative effects. One of the cutting-edge subfields of controlled medication administration is the oral drug delivery system. The most significant benefit of such a dose form is patient compliance. Sustained release dosage forms are designed to release a medicine at a set rate in order to keep the drug concentration constant for a set amount of time with the fewest side effects. By eliminating fluctuations in the therapeutic concentration of a medicine in the body, sustained release formulations are also offering a promising technique to reduce side effects of medication.
Keywords: Sustained Release, Controlled Drug Delivery System, Oral Drug Delivery System, Pharmacokinetics, Conventional Drug Therapy.