IDAAM Publications

Volume 1

July-December 2023

Polymorphism study of some organic compounds

Akshay R Yadav

Polymorphs of a compound are different crystal forms in which the lattice arrangement of molecules are dissimilar. These distinct solids usually have different melting points, solubilities, densities and optical properties. Many polymorphic compounds have flexible molecules that may assume different shapes of these solids shows that their crystal lattices impose certain conformational constraints. When melted or in solution, different polymorphic crystals of this kind produce the same rapidly equilibrating mixture or molecular species. Polymorphism is similar to, but distinct form, hydrated or solvated crystalline forms. It has been estimated that over many known organic compounds may be capable of polymorphism. Many pharmaceutical compounds exist in different crystalline forms and thus exhibit polymorphism. Polymorphism may affect chemical and Physical Stability, apparent solubility, dissolution, bioavailability and bioequivalence and manufacturability of drug product, which require special attention during product development as it affects the quality, safety and efficacy of drug product. In this article we had performed polymorphism study of some synthesized compounds and identified their shapes by using motic microscope.
Keywords: Polymorphism, Crystalline Forms, Chemical Stability, Motic Microscope.