IDAAM Publications

Volume 1

January-March 2023

Nanosponges drug delivery: A concise review ‎

Jyoti D Mhoprekar, Jameel Ahmed S Mulla‎

The modernization of the drug delivery system is a continuous process. Any delivery strategy that targets a molecule to delivery, Solubility, or a specific location is always welcome. This need can be met with polymers, Crosslinkers a specific drug delivery technology that can easily target the medicine at the site of action while maintaining efficacy and quality. Few new medications can be effectively given using traditional dose forms. Nanosponge technology has been developed to aid in the regulated release of drugs over time, reducing systemic toxicity and severe reactions. Nanosponges are microscopic sponges roughly the virus’s size (250 nm-1 µm) with cavities that can be filled with a range of hydrophilic and hydrophobic medications and then placed into a pharmaceutical dosage form such oral, parenteral, topical, or inhalation. The technology of nanosponges has been extensively researched for delivery of the drugs for oral, topical and parenteral administration. They can be prepared by different methods of preparation. The invention of nanosponge has shown to be a significant step forward in overcoming issues such as drug toxicity, low bioavailability, physiochemical instability, and patient unacceptability. It can be used as a shipper for biocatalyst in the transport and release of enzymes, vaccines, proteins, and antibodies. In this review, we look at nanosponges in general, their advantages and disadvantages, mechanisms, factors influencing nanosponges, method of preparation and different pharmaceutical dosage of formulations, evaluation parameters and applications.
Keywords: Nanosponge, Controlled Release, Solubility, Targeted Drug Delivery, Mechanism.