IDAAM Publications

Volume 1

January-March 2023

Emerging formulation tool for drug delivery: Self nano-‎emulsifying drug ‎delivery system (SNEDDS)‎ ‎​

Akshay R Yadav

Oral delivery of lipophilic drugs faces major challenges due to low aqueous solubility of such ‎compounds. Self Nano-emulsifying drug delivery systems (SNEDDSs) have ability to ‎increase solubility and bioavailability poorly soluble drugs. SNEDDS are isotropic mixtures of ‎oils, surfactants, solvents and co-solvents/co-surfactants that can be used for the design of ‎formulations in order to improve oral absorption of highly llipophilic drug compounds. The ‎Self Nanoemulsifying Drug Delivery System (SNEDDS) is important application on BCS ‎class II and class VI drugs for improving water solubility of poorly water soluble drugs and ‎improve bioavailability. Various surfactants and oils were screened as candidates for ‎SNEDDS on the basis of droplet size of resulting emulsions. This review offers an updated ‎overview of SNEDDS application from the biopharmaceutical point of view.‎‎
Keywords: Self Nano-Emulsifying Drug Delivery Systems, Isotropic Mixtures, BCS Class, HLB Value.