IDAAM Publications

Volume 1

January-March 2023

Molecular docking studies on phytoconstituents of Barleria prionitis ‎L. ‎against α-amylase enzyme ‎

Akshay R Yadav , Aishwarya C Patil, Yogita T Rayate, Prashant S ‎Salunkhe, Pravin P Honmane‎

The objective of the analysis is to determine the inhibitory function of α-amylase active ‎compounds in Barleria prionitis L. Usage in studies of silico docking. In this respect the docking ‎evaluation was for active plant constituent ligands. The standard inhibitor was acarbose, a known ‎α-amylase inhibitor. The latest version of GLIDE Software v5.5 developed by Schrödinger has ‎taken the place of silico docking studies. These results demonstrate that binding energy ranged ‎from – 3.1 to -8.9 kcal/mol in all active components. If compared (-6.3 kcal/mol) to the norm. The ‎inhibitors of α-amylase are excellent because of their structural parameters, as well as 1,8-‎dihydroxy-2,7-dimethyl 3,6-dimethoxy anthraquinone and Melilotic acid and Barlerin. Through ‎these molecular docking studies, the effective α-amylase inhibitors for the treatment of diabetes ‎are further developed.‎‎
Keywords: Barleria prionitis L., Molecular Docking, α-Amylase, Anti-diabetic.‎