6. Characterization Techniques of Solid Lipid Nanoparticles – IDAAM Publications

Solid Lipid Nanoparticles: Fundamentals, Design and Applications

Chapter 6 - Characterization Techniques of Solid Lipid Nanoparticles

K. Snekha, R. Susmitha, V. Sabitha, P. Gokulram, N. Selvasudha

Abstract:
Solid lipid nanoparticles (SLNs) have emerged as a promising nanocarrier system for drug delivery. Since they can encapsulate both hydrophobic and hydrophilic drugs and have the potential for controlled release. The main methods and variables used in the characterization of SLNs are thoroughly covered in this chapter. The significance of comprehending the physicochemical characteristics of SLNs, such as particle size, zeta potential, surface morphology, and crystalline structure, is covered at the outset. A number of analytical methods are thoroughly examined, including X-ray diffraction (XRD), differential scanning calorimetry (DSC), scanning and transmission electron microscopy (SEM/TEM), dynamic light scattering (DLS), and Fourier-transform infrared spectroscopy (FTIR). Methods for assessing drug encapsulation efficiency, in vitro release profiles, and stability under various storage conditions are also covered in this chapter. This chapter seeks to assist researchers in maximizing formulation and guaranteeing quality control in both academic and industrial contexts by providing insights into the approaches and difficulties in SLN characterization.

Keywords: Nanocarrier, Characterization, Particle size, Encapsulation efficiency, SEM.

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