Abstract: The present study depicts synthesis of a series of some novel 1,3,4-oxadiazole. The compounds were evaluated for their anti-inflammatory activity. 1,3,4-oxadiazole derivatives are very well-known biologically active N-containing heterocycles and represent a versatile lead molecule for designing potential bioactive agents. The widespread use of 1,3,4-oxadiazoles as a scaffold in medicinal chemistry establishes this moiety as a member of the privileged structures class. This pharmacological activity evaluation revealed that, among all the compounds screened, compound code 3a was found to have promising anti-inflammatory activity.