Abstract: Bicyclic heterocycles with a position nitrogen atom are found in many biologically active compounds. [1,2-a] imidazo pharmacologically active compounds with pyrimidine structural moieties include benzodiazepine receptor agonists, anti-inflammatory agents, gastric acid secretion inhibitors, calcium channel blockers, and antibacterials. In previous research imidazo [1,2-a]pyrimidine derivatives with help of docking study and pharmacological activity was found to be antiepileptic activity in present student study we tried to explore its ADME prediction. SwissADME is tool focus on specific property and it is most relevant computational methods provides pharmacokinetics properties of small molecules. A various in-silico methods share the aim of ADME prediction from molecular structure. The ADME properties including blood brain barrier, GI absorption, aqueous solubility and skin permeability were evaluated for these molecules. ADME screening was carried out to know efficacy of molecules before proceeding to in-vivo or in-vitro assays.
