Abstract: 
Natural products derived from plants have been extensively researched for their therapeutic potential. This study focuses on the formulation and evaluation of a Murraya koenigii leaf extract-based gel for topical application with antibacterial properties. Murraya koenigii, also known as curry leaves, is known for its antioxidant, anti-inflammatory, and antimicrobial properties. The formulated gel was characterized through various physical evaluations, including colour, Odor, consistency, pH, viscosity, spreadability, and washability. The gel exhibited good viscosity (6256 cp), excellent spreadability (7.4 gm.cm/sec), and a pH of 6.4, making it suitable for topical application. Antibacterial efficacy was tested against Staphylococcus aureus, showing a significant zone of inhibition (19.625 cm). The in vitro drug release study revealed a rapid initial release (40% in 15 minutes), followed by a sustained release over 300 minutes (95% cumulative release). These results suggest that Murraya koenigii leaf extract gel has potential as a plant-based antibacterial treatment, providing both immediate and prolonged therapeutic effects for bacterial skin infections.

Keywords: Murraya koenigii, Curry Leaves, Antibacterial Gel, Topical Application, Staphylococcus aureus, In Vitro Drug Release, Herbal Formulation, Plant-based Antibacterial Agent.