Abstract: Recent attention has been focused on the utilization of new polymers, which hold significant promise across various applications. The unique significance of dermatological pharmacology stems from the skin’s direct accessibility as a target organ for diagnostics and treatment. The skin’s unique composition poses challenges for drug delivery, as both hydrophilic and hydrophobic substances encounter barriers formed by the interaction between hydrophilic cornified cells and hydrophobic intercellular material. To address these challenges, emulgel has emerged as a notable solution. Emulgel, a blend of gel and emulsion, presents a promising method for delivering hydrophobic medicines effectively. It offers dual release controls through its gel and emulsion components. It is transparent, facilitating visibility of the application area, and emollient, leaving the skin feeling soft and moisturized. Moreover, emulgel is greaseless, ensuring a non-oily application experience. Its formulation enables easy spreading and detachment from the skin, enhancing usability and adherence. By mixing a surfactant with a co-surfactant, emulgel is a preparation with low interfacial tension and strong thermodynamic stability. It has various features, including enhanced permeability and good thermodynamic stability. The formulation is evaluated for a number of characteristics, including as skin irritancy, medication content, pH, viscosity, particle size, zeta potential, and other pertinent elements.
