Abstract: 
Direct tableting is a modern method for pharmaceutical materials; it needs to have good micromeretics properties. The aim of this study was to prepare and evaluate spherical agglomerates of an anti-diabetic drug (Glimepiride) by spherical agglomeration technique to improve physicochemical properties of the BCS Class II Drug. Spherical agglomerates are prepared by using PVP K30, PEG6000 as polymer in the various concentrations i.e. 1%, 2%, 3% respectively with DCM as good solvent and water as bad solvent. GLM and PVP K30 having the conc. of 3% shows the satisfactory results than other polymers and conc. Spherical crystals characterized by angle of repose, Hauser’s ratio, Cars index, Bulk density, Tapped Density, SEM,  and in-vitro drug release. The spherical crystals show good dissolution profile. The data were obtained of all parameters are satisfactory. Tablet of agglomerates was prepared by mixing drug with excipients by direct compression method. Evaluation parameters of optimized batch and gives satisfactory results, like weight variation, hardness of the tablet, friability, thickness, disintegration test, drug content uniformity and in vitro drug release studies were performed. The water solubility of spherical crystals of Glimepiride was increased as compared with pure drug. The prepared crystals that having the changed size and shape that significantly responsible for the improvement in the flow ability, solubility and dissolution properties of Glimepiride agglomerates. The micrometrics properties of agglomerates were significantly improved, resulting in successful direct tableting. Prepared tablet from spherical agglomerates with excipients showed good physicochemical properties.

Keywords: Spherical Crystallization, Direct Compression, Flowability, Micromeretic Properties, Glimepiride.