Solid Lipid Nanoparticles: Fundamentals, Design and Applications
Chapter 4 - Lipid Selection and Drug Compatibility
Lavanya Yaidikar, Prasanthi K, Lavanya Mandapati
Abstract:
Lipid-loaded drug delivery vehicles such as liposomes, lipid nanoparticles (LNPs) and emulsions hold great promise towards solving some of the problems related to drug solubility, stability, and targeted drug delivery since these delivery vehicles are lipid-based. Lipids preserve both water based and fat based drugs and their amphiphillic nature increases their bioavailabilities and can provide controlled or sustained release. Effective formulations of lipid-based formulations require the interaction of the drug and the lipid matrix to be compatible; compatibility affects the drug loading, the release kinetics, and stability, besides the bioavailability of the drug. This chapter examines how lipids may be used in drug delivery and in what criteria a lipid should be chosen, and how the lipid preparations may be adjusted to achieve a better therapeutic effect. Some of the considerations such as drug-lipid interactions, phase behavior, and drug biocompatibility among others are addressed to show the significance of using the appropriate lipid when necessary to produce intended therapeutic effects. Further, the approaches that could elevate lipid-drug compatibility like lipid modification and lipid mixing are also presented, as well as the use of the systems in the development of cancer treatment, gene, and vaccine delivery.
Keywords:
Lipid based drug delivery systems, liposomes, lipid nanoparticles, controlled release, drug targeting, biocompatibility.
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