ADMET analysis novel 2,5-substituted aryl-7-phenyl-1,3,4-oxadiazolo-[3,2-a]-1,3,5-triazine derivatives against Urease protein and Helicobacter pylori bacterium
Abstract: Absorption, distribution, metabolism, and excretion (ADME) analysis is becoming more common earlier in the drug development process, at a time when the number of potential compounds is increasing but access to physical samples is limited. ADMET studies have also been performed using the SwissADME web tool to verify the pharmacological similarity of designed compounds. In-silico study was used to design drug candidates against the urease enzyme that was found to cause many pathological disorders in humans and in animals. Studies on a designed library have previously been carried out with 2,5-substituted aryl-7-phenyl-1,3,4-oxadiazolo-[3,2-a]-1,3,5-triazine Derivatives. Hence, the present investigation studies will provide a new vision for the discovery of potent agents against H. pylori and urease associated diseases.
