Abstract: Drugs that target cellular microtubules can be divided into two groups, microtubule stabilizers and microtubule destabilizers, on the basis of their effects on tubulin polymerization and cellular microtubules. In previous research triazole derivatives with help of docking study and pharmacological activity was found to be tubulin inhibitor in present student study we tried to explore its ADME prediction.The ADME properties including blood brain barrier, GI absorption, aqueous solubility and skin permeability were evaluated for these molecules. A various in-silico methods share the aim of ADME prediction from molecular structure. SwissADME is tool focus on specific property and it is most relevant computational methodsprovides pharmacokinetics properties of small molecules. ADME screening was carried out to know efficacy of molecules before proceeding to in-vivo or in-vitro assays.
